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Article

Overexpression of S100A4 in human cancer cell lines resistant to methotrexate

1 Jun 2010

Abstract excerpt

BACKGROUND: Methotrexate is a chemotherapeutic drug that is used in therapy of a wide variety of cancers. The efficiency of treatment with this drug is compromised by the appearance of resistance. Combination treatments of MTX with other drugs that could modulate the expression of genes involved in MTX resistance would be an adequate strategy to prevent the development of this resistance. METHODS: The...

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PMID: 20515499
DOI: 10.1186/1471-2407-10-250

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