Article
Methotrexate resistance in vitro is achieved by a dynamic selectionprocess of tumor cell variants emerging during treatment.
International journal of cancer - 1 Oct 2006
de Anta Josep M, Mayo Clara, Solé Francesc, Salido Marta, Espinet Blanca, Corzo Cristina, Petzold Myriam, Villa Olaya, Serrano Sergi, Real Francisco X, Mayol Xavier
Abstract excerpt
Genetic instability leads to tumor heterogeneity, which in turn provides a source of cell variants responsible for drug resistance. However, the source of resistant cells during the process of acquired resistance is poorly understood. Our aim has been to characterize the mechanism by which acquired resistance to methotrexate emerges during the course of cancer cell treatment in vitro. We recently demonstrated...
Topics
- Cell Line, Tumor
- Cell Proliferation
- Chromosomal Instability
- Dipyridamole
- Drug Resistance, Neoplasm
- Genetic Variation
- Humans
- Methotrexate
- Neoplasms
- Nucleosides
- Selection, Genetic