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Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells

1 Feb 2009

Abstract excerpt

Gene amplification is one of the most frequent manifestations of genomic instability in human tumors and plays an important role in tumor progression and acquisition of drug resistance. To better understand the factors involved in acquired resistance to cytotoxic drugs via gene amplification, we have analyzed the structure and dynamics of dihydrofolate reductase (DHFR) gene amplification in HT29 cells treated...

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PMID: 19190117
DOI: 10.1158/1535-7163.mct-08-0759

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Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cellsPMID 19190117Read ↗

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