Article
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI.
The Biochemical journal - 15 May 1998
Zingg J M, Shen J C, Jones P A
Abstract excerpt
Most prokaryotic (cytosine-5)-DNA methyltransferases increase the frequency of deamination at the cytosine targeted for methylation in vitro in the absence of the cofactor S-adenosylmethionine (AdoMet) or the reaction product S-adenosylhomocysteine (AdoHcy). We show here that, under the same in vitro conditions, the prokaryotic methyltransferase, M.MspI (from Moraxella sp.), causes very few cytosine deaminations,...
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