Article
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI.
The Biochemical journal - 15 May 1998
Zingg J M, Shen J C, Jones P A
Abstract excerpt
Most prokaryotic (cytosine-5)-DNA methyltransferases increase the frequency of deamination at the cytosine targeted for methylation in vitro in the absence of the cofactor S-adenosylmethionine (AdoMet) or the reaction product S-adenosylhomocysteine (AdoHcy). We show here that, under the same in v...
Topics
- Adenosine
- Bacterial Proteins
- Cytosine
- DNA (Cytosine-5-)-Methyltransferases
- DNA-Binding Proteins
- Deamination
- Deoxyadenosines
- Molecular Structure
- Moraxella
- Mutation
- Neomycin
- S-Adenosylhomocysteine
- S-Adenosylmethionine