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Article

Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase.

Nucleic acids research - 1 May 2011

Gerasimaitė Rūta, Merkienė Eglė, Klimašauskas Saulius

Abstract excerpt

Methylation of the five position of cytosine in DNA plays important roles in epigenetic regulation in diverse organisms including humans. The transfer of methyl groups from the cofactor S-adenosyl-L-methionine is carried out by methyltransferase enzymes. Using the paradigm bacterial methyltransfe...

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Identifiers

PMID: 21245034
DOI: 10.1093/nar/gkq1329
PMCID: PMC3089467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21245034-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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