Article
Aberrant processing of Fas transcripts in adult T-cell leukemia: a possible role in tumor cell survival.
Cancer letters - 25 Apr 2003
Tawara Masayuki, Maeda Takahiro, Yamada Yasuaki, Harasawa Hitomi, Tsuruda Kazuto, Sugahara Kazuyuki, Moriuchi Ryozo, Tomonaga Masao, Kamihira Shimeru
Abstract excerpt
In adult T-cell leukemia (ATL), tumor cells commonly express abundant membrane-bound Fas antigen. We reported a significant correlation between Fas expression status of ATL patients and their clinical outcome. In the current study, we analyzed the Fas cDNA sequence of the distinctive ATL cases that barely expressed mFas identified during the previous study. According to the results, changes in the Fas amino acid...
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