Article
Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene.
Diabetes - 1 Mar 2001
Weisnagel S J, Rankinen T, Nadeau A, Rao D C, Chagnon Y C, Pérusse L, Bouchard C
Abstract excerpt
The high-affinity sulfonylurea receptor 1 (SUR1) plays an important role in regulating insulin secretion. In the Québec Family Study, we genotyped 731 individuals (685 nondiabetic [ND] subjects) for the SUR1 gene IVS15-3c-->t and exon 18 Thr759(ACC-->ACT) polymorphisms using polymerase chain reac...
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