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Article

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

Lancet (London, England) - 25 Jan 2003

Huopio Hanna, Otonkoski Timo, Vauhkonen Ilkka, Reimann Frank, Ashcroft Frances M, Laakso Markku

Abstract excerpt

BACKGROUND: ATP-sensitive potassium (KATP) channels are major regulators of glucose-induced insulin secretion in pancreatic beta cells. We have described a dominant heterozygous mutation--E1506K--in the sulfonylurea receptor 1 (SUR1) gene (ABCC8) in a Finnish family, which leads to congenital hyperinsulinaemia due to reduction of K(ATP)-channel activity. We aimed to characterise glucose metabolism in adults...

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Source

Identifiers

PMID: 12559865
DOI: 10.1016/S0140-6736(03)12325-2

Genes

ABCC8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.PMID 12559865Read ↗

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