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Article

Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.

Diabetologia - 1 Apr 2000

Hart L M, Dekker J M, van Haeften T W, Ruige J B, Stehouwer C D, Erkelens D W, Heine R J, Maassen J A

Abstract excerpt

AIMS/HYPOTHESIS: The sulphonylurea receptor is a subunit of the ATP-sensitive potassium channel in the pancreatic beta cell. Mutations at nt -3 of the splice acceptor site of exon 16 and a silent mutation in exon 18 of the gene for the sulphonylurea receptor (SUR1) associate with Type II (non-insulin-dependent) diabetes mellitus in several independent populations. We investigated whether these gene variants...

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Identifiers

PMID: 10819247
DOI: 10.1007/s001250051337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.PMID 10819247Read ↗

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