Article
Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes.
Fundamental & clinical pharmacology - 1 Dec 2010
Alvarez Santi, Mas Sergi, Gassó Patricia, Bernardo Miquel, Parellada Eduard, Lafuente Amalia
Abstract excerpt
We investigated the relationship between several functional polymorphisms in genes coding for dopamine metabolism and transport enzymes (MAO-A VNTR; MAO-A 941T>G; DAT VNTR; DAT -67A/T; CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*6) and the frequency of schizophrenia. Participants in the study were 242 subjects diagnosed with schizophrenia and related disorders and 290 hospital-based controls. Genomic DNA was isolated...
Topics
- Adult
- Alleles
- Cytochrome P-450 CYP2D6
- Dopamine
- Dopamine Plasma Membrane Transport Proteins
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Minisatellite Repeats
- Monoamine Oxidase
- Polymorphism, Genetic
- Schizophrenia