Article
Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or CYP2D6B.
Psychiatric genetics - 1 Jan 1997
Kawanishi C, Hanihara T, Maruyama Y, Matsumura T, Onishi H, Inoue K, Sugiyama N, Suzuki K, Yamada Y, Kosaka K
Abstract excerpt
To examine a possible association between debrisoquine 4-hydroxylase gene mutations and neuroleptic malignant syndrome, we assessed frequencies of wild type and A and B mutant alleles of the CYP2D6 gene in 24 patients with a history of neuroleptic malignant syndrome, 50 patients with neuroleptic-...
Topics
- Alleles
- Cytochrome P-450 CYP2D6
- DNA
- Gene Frequency
- Genotype
- Homozygote
- Humans
- Neuroleptic Malignant Syndrome
- Reference Values
- Schizophrenia