Article
Identification of CYP2D6 null variants among long-stay, chronic psychiatric inpatients: is it strictly necessary?
Human psychopharmacology - 1 Aug 2008
Fernández-Santander Ana, Santiago Catalina, Díez-Durán Sarai, González María, de Castro Emilia, Guijarro Jorge, Bandrés Fernando, Lucia Alejandro, Gómez-Gallego Félix
Abstract excerpt
We identified the null variants *3,*4,*5,*6,*7 and *8 of the CYP2D6 gene [encoding for cytochrome P450 (debrisoquine hydroxylase)] in a group of 84 chronic-stay psychiatric inpatients with severe schizophrenia or related disorders and receiving treatment with one or more CYP2D6 substrates for years. We also studied a group of 100 healthy controls of similar ethnic origin (Spanish Caucasians). Three patients were...
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