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The downregulation of CD4 and MHC‐I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

1 Apr 1999

Abstract excerpt

The human and simian immunodeficiency viruses (HIV and SIV) downregulate the cell surface expression of CD4, their primary receptor, and of class I histocompatibility complex (MHC-I), a critical mediator of immune recognition. While the first of these effects seems important to preserve viral infectivity, the second likely promotes immune evasion. Three HIV-1 proteins, Nef, Env and Vpu, contribute to downregulate...

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PMID: 10399064
DOI: 10.1111/j.1600-065x.1999.tb01282.x

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The downregulation of CD4 and MHC‐I by primate lentiviruses: a paradigm for the modulation of cell surface receptorsPMID 10399064Read ↗

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