Alterations of the p53 tumor-suppressor gene and K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area.

doi:10.1002/(sici)1097-0215(19981209)78:6<695::aid-ijc5>3.0.co;2-8

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Article

Alterations of the p53 tumor-suppressor gene and K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area.

International journal of cancer - 9 Dec 1998

Sturm P D, Baas I O, Clement M J, Nakeeb A, Johan G, Offerhaus A, Hruban R H, Pitt H A

Abstract excerpt

We observed a clustering of cholangiocarcinoma in a part of West Virginia. We analyzed the frequency and type of alterations in the p53 tumor-suppressor gene and the K-ras oncogene to determine whether cholangiocarcinomas from this high-incidence area differ from other cholangiocarcinomas at the...

Topics

Adult
Aged
Cholangiocarcinoma
Female
Genes, p53
Genes, ras
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Tumor Suppressor Protein p53
West Virginia

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