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Article

APR-246 as a radiosensitization strategy for mutant p53 cancers treated with alpha-particles-based radiotherapy.

Cell death & disease - 18 Jun 2024

Michaeli Or, Luz Ishai, Vatarescu Maayan, Manko Tal, Weizman Noam, Korotinsky Yevgeniya, Tsitrina Alexandra, Braiman Alex, Arazi Lior, Cooks Tomer

Abstract excerpt

Radiation therapy (RT) remains a common treatment for cancer patients worldwide, despite the development of targeted biological compounds and immunotherapeutic drugs. The challenge in RT lies in delivering a lethal dose to the cancerous site while sparing the surrounding healthy tissues. Low linear energy transfer (low-LET) and high linear energy transfer (high-LET) radiations have distinct effects on cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38890278
DOI: 10.1038/s41419-024-06830-3
PMCID: PMC11189442

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