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Article

Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation.

Molecular biology of the cell - 1 Apr 2003

Goehring April S, Mitchell David A, Tong Amy Hin Yan, Keniry Megan E, Boone Charles, Sprague George F

Abstract excerpt

The p21-activated kinases Ste20p and Cla4p carry out undefined functions that are essential for viability during budding in Saccharomyces cerevisiae. To gain insight into the roles of Ste20p, we have used a synthetic lethal mutant screen to identify additional genes that are required in the absence of Cla4p. Altogether, we identified 65 genes, including genes with roles in cell polarity, mitosis, and cell wall...

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Identifiers

PMID: 12686605
DOI: 10.1091/mbc.e02-06-0348
PMCID: PMC153118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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