Article
Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas.
The Journal of investigative dermatology - 1 Oct 2006
Ponti Giovanni, Losi Lorena, Pedroni Monica, Lucci-Cordisco Emanuela, Di Gregorio Carmela, Pellacani Giovanni, Seidenari Stefania
Abstract excerpt
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal-dominant disorder characterized by predisposition to colorectal cancer and extracolonic malignancies, frequent multiple primary tumors in the same patient, and early age of cancer onset. A main clinical variant of Lynch syndrome, Muir-Torre syndrome (MTS) is characterized by the association between one or more visceral malignancies, with at least...
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