Article
Molecular genetics of small cell lung carcinoma.
Seminars in oncology - 1 Apr 2001
Wistuba I I, Gazdar A F, Minna J D
Abstract excerpt
The etiology of small cell lung cancer (SCLC) is strongly tied to cigarette smoking, and now there is considerable information concerning molecular abnormalities involved in the pathogenesis of SCLC. Autocrine growth factors such as neuroendocrine regulatory peptides (eg, bombesin/gastrin-releasing peptide) are prominent in SCLC. Dominant oncogenes of the Myc family are frequently overexpressed in both SCLC and...
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