Article
Whatever happened to SRY?
Cellular and molecular life sciences : CMLS - 1 Dec 1999
O'Neill M J, O'Neill R J
Abstract excerpt
The mammalian sex-determining gene, SRY, was identified by positional cloning approximately 10 years ago. Since its discovery, intense research into this gene has been directed on two main fronts: elucidation of its function in development of the testis and examination of its singular evolutionary history. The role or SRY as the testis-determining factor (TDF) places it at a crucial point in the highly conserved...
Topics
- Amino Acid Sequence
- Animals
- Conserved Sequence
- DNA-Binding Proteins
- Evolution, Molecular
- Humans
- Kruppel-Like Transcription Factors
- Male
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Sequence Alignment
- Sex Determination Processes
- Sex-Determining Region Y Protein
- Testis
- Transcription Factors
- Y Chromosome