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Article

Up‐regulation of SOX9 in human <i>sex‐determining region on the Y chromosome (SRY)</i>‐negative XX males

8 Oct 2007

Abstract excerpt

BACKGROUND: In mammals, gonadal sex is normally determined by the presence or absence of the Y chromosome gene SRY. After expression of SRY in the sexually indifferent gonad, a number of genes encoding transcription factors and growth factors implicated in testis differentiation start to show male-specific expression. However, in XX males, these genes must be up-regulated in the absence of SRY, but the aetiology...

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PMID: 17986281
DOI: 10.1111/j.1365-2265.2007.03101.x

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