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Article

From SRY to SOX9: Mammalian Testis Differentiation

1 Jul 2005

Abstract excerpt

Sry (sex-determining region on the Y chromosome) is a master gene that initiates testis differentiation of the bipotential indifferent gonad in mammals. In mice, Sry expression is transiently activated in a center-to-pole wave along the anteroposterior (AP) axis of developing XY gonads. Shortly after the onset of Sry activation, Sox9 (Sry-related HMG box-9), a fundamental testis-differentiation gene common to all...

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PMID: 16046443
DOI: 10.1093/jb/mvi098

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