2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system.

doi:10.1006/taap.2002.9396

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Article

2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system.

Toxicology and applied pharmacology - 1 May 2002

Wyman Amber, Lavin Amy L, Wilding Gregory E, Gasiewicz Thomas A

Abstract excerpt

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), acting through the aromatic hydrocarbon receptor (AhR), elicits numerous toxicological effects, including immunosuppression. Previous work from our laboratory has suggested that TCDD exposure in mice is associated with altered lymphopoietic development, in particular altered B-cell phenotype in the bone marrow. It remains to be determined which specific hematopoietic...

Topics

Animals
B-Lymphocytes
Bone Marrow
Coculture Techniques
Environmental Pollutants
Flow Cytometry
Growth
Hematopoiesis
Male
Mice
Mice, Inbred C57BL
Phenotype
Polychlorinated Dibenzodioxins
Receptors, Aryl Hydrocarbon

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Open in PubMed

Identifiers

PMID: 12009856
DOI: 10.1006/taap.2002.9396

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