Article
The insulin gene region and susceptibility to insulin-dependent diabetes mellitus in four races; new insights from Afro-Caribbean race-specific haplotypes.
Autoimmunity - 1 Jan 1997
Mijovic C H, Penny M A, Jenkins D, Jacobs K, Heward J, Knight S W, Lucassen A, Morrison E, Barnett A H
Abstract excerpt
The IDDM2 component of the genetic susceptibility to insulin-dependent diabetes mellitus (IDDM) has been mapped to chromosome 11p15.5. The exact identity of IDDM2 remains uncertain. It has been suggested that IDDM2 maps within the 5' VNTR (variable number tandem repeat) polymorphism upstream of the insulin gene (INS). This has not been confirmed and a contribution from other INS gene region polymorphisms cannot...
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