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Article

Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 1998

de Villiers W J, Smith J D, Miyata M, Dansky H M, Darley E, Gordon S

Abstract excerpt

Mice deficient in both macrophage-colony-stimulating factor (M-CSF, op) and apolipoprotein E (apoE) have elevated cholesterol levels but are protected from atherosclerosis. To assess the contribution of macrophage (Mphi) phenotypic heterogeneity and scavenger receptor (SR-A) expression to this seeming paradox, we characterized the Mphi phenotype by immunohistochemistry in these animals. Lesion size was determined...

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Identifiers

PMID: 9555870
DOI: 10.1161/01.atv.18.4.631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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