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Article

Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis.

PLoS neglected tropical diseases - 1 Apr 2018

Qiu Li, Patterson Steven E, Bonnac Laurent F, Geraghty Robert J

Abstract excerpt

Dengue virus affects millions of people worldwide each year. To date, there is no drug for the treatment of dengue-associated disease. Nucleosides are effective antivirals and work by inhibiting the accurate replication of the viral genome. Nucleobases offer a cheaper alternative to nucleosides for broad antiviral applications. Metabolic activation of nucleobases involves condensation with...

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Identifiers

PMID: 29672522
DOI: 10.1371/journal.pntd.0006421
PMCID: PMC5929572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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