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Article

Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.

Journal of medicinal chemistry - 2 Jun 2005

Wang Jianing, Jin Yunho, Rapp Kimberly L, Bennett Matthew, Schinazi Raymond F, Chu Chung K

Abstract excerpt

Carbocyclic nucleosides have received much attention due to their interesting biological activity and metabolic stability. Among nucleoside analogues, a fluorine substitution on the carbohydrate moiety or introduction of a 2',3'-unsaturated structure motif has been proven to be successful in producing effective antiviral agents. By combining these structural features, both D- and...

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PMID: 15916425
DOI: 10.1021/jm050096d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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