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Article

Oral tolerance as therapy for experimental autoimmune encephalomyelitis and multiple sclerosis: demonstration of T cell anergy.

Immunology and cell biology - 1 Feb 1998

Jewell S D, Gienapp I E, Cox K L, Whitacre C C

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is an important model for developing therapies for multiple sclerosis (MS). The oral administration of the central nervous system antigen, myelin basic protein (MBP), to Lewis rats and susceptible mouse strains prior to MBP immunization prevents the induction of EAE. Clinical trials administering myelin orally to MS patients have met with only partial success, and...

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Source

Identifiers

PMID: 9553779
DOI: 10.1046/j.1440-1711.1998.00716.x

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oral tolerance as therapy for experimental autoimmune encephalomyelitis and multiple sclerosis: demonstration of T cell anergy.PMID 9553779Read ↗

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of AutoantigensSemantic proximity Read ↗

Oral tolerance in experimental autoimmune encephalomyelitis: specificity of peptide-induced oral tolerance.Semantic proximity Read ↗

Tolerance induction by bone marrow transplantation in a multiple sclerosis model.Semantic proximity Read ↗

Persistence of peptide-induced CD4+ T cell anergy in vitro.Semantic proximity Read ↗

Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopes.Semantic proximity Read ↗

Oral administration of live virus protects susceptible mice from developing Theiler's virus-induced demyelinating disease.Semantic proximity Read ↗

Adoptive transfer of experimental allergic encephalomyelitis: recipient response to myelin basic protein-reactive lymphocytes.Semantic proximity Read ↗

Superantigen-reactive T cells that display an anergic phenotype in vitro appear functional in vivo.Semantic proximity Read ↗

IL-4 and IL-10 Are Both Required for the Induction of Oral ToleranceSemantic proximity Read ↗

Quantitation of myelin oligodendrocyte glycoprotein and myelin basic protein in the thymus and central nervous system and its relationship to the clinicopathologic features of autoimmune encephalomyelitis.Semantic proximity Read ↗

Myelin-liposome protection against experimental autoimmune encephalomyelitis is associated with reduced neuroantigen-specific T-cell-mediated responses.Semantic proximity Read ↗

Phenotypic analysis of oral tolerance to alloantigens: evidence that the indirect pathway of antigen presentation is involved.Semantic proximity Read ↗

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