Article
Myelin-liposome protection against experimental autoimmune encephalomyelitis is associated with reduced neuroantigen-specific T-cell-mediated responses.
Cellular immunology - 1 Jan 1993
Stein C S, St Louis J, Strejan G H
Abstract excerpt
Lewis rats undergo a relapsing paralytic disease upon challenge with spinal cord emulsified in complete Freund's adjuvant (CFA). Treatment with two intracardiac injections of liposomes composed of whole myelin significantly reduced the severity of disease. Protection was disease-specific since tr...
Topics
- Animals
- Cell Division
- Cells, Cultured
- Encephalomyelitis, Autoimmune, Experimental
- Female
- Hypersensitivity, Delayed
- Liposomes
- Lymph Nodes
- Lymphocyte Activation
- Myelin Proteins
- Phenotype
- Rats
- Rats, Inbred Lew
- Spleen
- T-Lymphocytes