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IL-4 and IL-10 Are Both Required for the Induction of Oral Tolerance

1 Mar 1999

Abstract excerpt

Protection from the development of experimental autoimmune uveitis (EAU) can be induced by feeding mice interphotoreceptor retinoid binding protein before uveitogenic challenge with the same protein. Two different regimens are equally effective in inducing protective tolerance, although they seem to do so through different mechanisms: one involving regulatory cytokines (IL-4, IL-10, and TGF-beta), and the other...

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PMID: 10072503
DOI: 10.4049/jimmunol.162.5.2613

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