Article
Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively.
Immunogenetics - 1 Mar 2002
Sashio Hiroko, Tamura Kazuo, Ito Reiko, Yamamoto Yoshihiro, Bamba Hiroko, Kosaka Tadashi, Fukui Shin, Sawada Koji, Fukuda Yoshihiro, Tamura Kazutami, Satomi Masamichi, Shimoyama Takashi, Furuyama Jun-ichi
Abstract excerpt
The importance of tumor necrosis factor (TNF)-alpha and the TNF receptor gene polymorphisms in the etipathogenesis of inflammatory bowel disease (IBD) has not been elucidated. DNA from peripheral blood samples was obtained from 124 patients with Crohn's disease (CD), 106 patients with ulcerative colitis (UC), and 111 unrelated healthy controls. We examined two single nucleotide polymorphisms (SNPs) of the...
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