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Article

An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 1996

Forcione D G, Sands B, Isselbacher K J, Rustgi A, Podolsky D K, Pillai S

Abstract excerpt

The role of inflammatory T cells in Crohn's disease suggests that inherited variations in major histocompatibility complex (MHC) class II genes may be of pathogenetic importance in inflammatory bowel disease. The absence of consistent and strong associations with MHC class II genes in Caucasian p...

Topics

Alleles
Case-Control Studies
Crohn Disease
Ethnicity
Gene Frequency
Genetic Linkage
HLA-DR Antigens
HLA-DRB1 Chains
HLA-DRB3 Chains
Humans
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8643533
DOI: 10.1073/pnas.93.10.5094
PMCID: PMC39412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8643533-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele.PMID 8643533Read ↗

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The distribution of HLA-DRB alleles in ulcerative colitis patients in Turkey.Semantic proximity Read ↗

Amino acid polymorphism at residue 71 in HLA-DR beta chain plays a critical role in susceptibility to ulcerative colitis.Semantic proximity Read ↗

Distinct associations of HLA class II genes with inflammatory bowel disease.Semantic proximity Read ↗

HLA-DRB1 alleles may influence disease phenotype in patients with inflammatory bowel disease: a critical reappraisal with review of the literature.Semantic proximity Read ↗

The incidence of HLA DRB1*0103 in ulcerative colitis patients in north-eastern Poland.Semantic proximity Read ↗

HLA class II gene frequencies in Crohn's disease: a population based analysis in Germany.Semantic proximity Read ↗

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HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations.Semantic proximity Read ↗

HLA-DRB1*03, but not the TNFA -308 promoter gene polymorphism, confers protection against fistulising Crohn's disease.Semantic proximity Read ↗

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