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Article

TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease.

The American journal of gastroenterology - 1 May 2003

González Segundo, Rodrigo Luis, Martínez-Borra Jesús, López-Vázquez Antonio, Fuentes Dolores, Niño Pilar, Cadahía Valle, Saro Cristina, Dieguez M Angeles, López-Larrea Carlos

Abstract excerpt

OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) plays a key role in the inflammatory response and pathogenesis of Crohn's disease (CD). TNF-alpha -308A polymorphism within the TNF-alpha gene promoter has been associated with enhanced TNF-alpha production in vitro. The aim of this study was to investigate the effect of TNF-alpha promoter polymorphism at -308 on the susceptibility and phenotypic expression of...

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Source

Identifiers

PMID: 12809834
DOI: 10.1111/j.1572-0241.2003.07416.x

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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