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Factors Influencing Recombinant Adeno-Associated Virus Production

20 Mar 1998

Abstract excerpt

Recombinant adeno-associated virus (rAAV) is produced by transfecting cells with two constructs: the rAAV vector plasmid and the rep-cap plasmid. After subsequent adenoviral infection, needed for rAAV replication and assembly, the virus is purified from total cell lysates through CsCl gradients. Because this is a long and complex procedure, the precise titration of rAAV stocks, as well as the measure of the level...

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Identifiers

PMID: 9551617
DOI: 10.1089/hum.1998.9.5-695

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