Article
Identification of a replication-defective herpes simplex virus for recombinant adeno-associated virus type 2 (rAAV2) particle assembly using stable producer cell lines.
The journal of gene medicine - 1 May 2004
Toublanc Estelle, Benraiss Abdellatif, Bonnin Delphine, Blouin Véronique, Brument Nicole, Cartier Nathalie, Epstein Alberto L, Moullier Philippe, Salvetti Anna
Abstract excerpt
BACKGROUND: The development of stable producer cell lines for recombinant adeno-associated virus (rAAV) assembly is a strategy followed by many groups to develop scalable production methods suitable for good manufacturing practice (GMP) requirements. The major drawback of this method lies in the requirement for replicating adenovirus (Ad) for rAAV assembly. In the present study, we analyzed the ability of several...
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