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Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors

22 Apr 2025

Abstract excerpt

Over the last two decades, adeno-associated viruses (AAVs) have been widely used as viral vectors in gene therapy due to their ability to infect both dividing and nondividing cells, broad tissue specificity, and favorable safety profile. Recombinant AAV (rAAV) production requires a helper virus, typically adenovirus (AdV), which provides essential genes for AAV replication. However, the increasing demand for...

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PMID: 40260496
DOI: 10.1089/hum.2024.265

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