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Article

High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 1998

Lezoualc'h F, Sagara Y, Holsboer F, Behl C

Abstract excerpt

Selected clones of the sympathetic precursor-like cell line PC12 (rCl8) are resistant to oxidative cell death induced by the Alzheimer's disease-associated amyloid beta protein (Abeta) and hydrogen peroxide (H2O2). Here, we show that the transcriptional activity and DNA binding activity of the redox-sensitive transcription factor NF-kappaB and its nuclear expression are constitutively increased in rCl8 cells...

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Identifiers

PMID: 9547231
PMCID: PMC6792651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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