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Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

15 Jan 1996

Abstract excerpt

Clones of the rat pheochromocytoma cell line PC12 were selected for their resistance to amyloid beta protein (A beta). These A beta-resistant cells also survive higher concentrations of exogenously applied peroxides than the parent cells. A beta triggers intracellular H2O2 accumulation in the parent PC12 cells but not in the A beta-resistant cells. The absence of H2O2 accumulation in A beta-resistant cells is not...

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PMID: 8551334
DOI: 10.1523/jneurosci.16-02-00497.1996

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