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Article

Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.

Brain research. Molecular brain research - 13 Jun 2005

Hamano Tadanori, Mutoh Tatsuro, Tabira Takeshi, Araki Wataru, Kuriyama Masaru, Mihara Takateru, Yano Shigeaki, Yamamoto Hiroko

Abstract excerpt

The pathogenesis of Alzheimer's disease (AD) is now thought to be tightly linked to Abeta deposition and oxidative stress, but it is still unknown how these factors result in neuronal dysfunction and cell death. Mutations of presenilin 1 (PS1) gene are the causative gene for early onset familial AD (FAD) due to the overproduction and deposition of pathogenic Abeta1-42 peptides. We report here the molecular...

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Identifiers

PMID: 15950763
DOI: 10.1016/j.molbrainres.2005.02.018

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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