Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis.

doi:10.1016/j.rdc.2017.04.003

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Article

Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis.

Rheumatic diseases clinics of North America - 1 Aug 2017

van Drongelen Vincent, Holoshitz Joseph

Abstract excerpt

The cause and pathogenesis of rheumatoid arthritis (RA) are influenced by environmental and genetic risk factors. Shared epitope-coding human leukocyte antigen (HLA)-DRB1 alleles increase RA risk and severity; however, the underlying mechanisms of action remain unclear. In contrast, several other DRB1 alleles protect against RA. Additionally, genome-wide association studies suggest that RA associates with other,...

Topics

Alleles
Arthritis, Rheumatoid
Epitopes
Gene-Environment Interaction
HLA Antigens
Humans

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Identifiers

PMID: 28711139
DOI: 10.1016/j.rdc.2017.04.003
PMCID: PMC5643023

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