Article
HLA associations with rheumatoid arthritis: a piece of the puzzle.
The Journal of rheumatology. Supplement - 1 Jan 1992
Gregersen P K
Abstract excerpt
HLA molecules play a central role in the immune response by presenting processed antigenic peptides to T cells. In the case of rheumatoid arthritis (RA), a specific sequence present within the peptide binding cleft of HLA class II molecules has been implicated in genetic susceptibility to this disease. Several mechanisms could account for this finding. One possibility, designated determinant selection, rests on...
Topics
- Alleles
- Animals
- Antibody Formation
- Arthritis, Rheumatoid
- Disease Susceptibility
- Epitopes
- HLA Antigens
- HLA-D Antigens
- Humans
- Mice
- Models, Genetic
- Racial Groups