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Article

Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis.

Journal of human genetics - 1 Nov 2015

Furukawa Hiroshi, Oka Shomi, Shimada Kota, Hashimoto Atsushi, Tohma Shigeto

Abstract excerpt

Human leukocyte antigen (HLA) polymorphisms are the most important genetic risk factors for rheumatoid arthritis (RA), a chronic systemic inflammatory disease of unknown etiology. Certain HLA-DRB1 alleles, known as shared epitope (SE) alleles because they have the same amino-acid sequence at positions 70-74, are associated with susceptibility to RA. A gene dosage effect is present for RA-predisposing SE alleles,...

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Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Hypersensitivity

Share to Drug-Induced Adverse Reactions

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 25903069
DOI: 10.1038/jhg.2015.36

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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