Article
Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity.
Obesity research - 1 Mar 1998
Rolland V, Clément K, Dugail I, Guy-Grand B, Basdevant A, Froguel P, Lavau M
Abstract excerpt
The massive obesity caused in rodents by the disruption of the leptin-receptor signal through genetic defects at the level of either leptin (OB) or leptin receptor (OB-R) has raised the question of the relevance of these genes to morbid obesity in humans. In this study, we screened a large popula...
Topics
- Adult
- Animals
- Carrier Proteins
- Deoxyribonucleases, Type II Site-Specific
- Diabetes Mellitus
- Exons
- Genotype
- Glutamine
- Humans
- Introns
- Middle Aged
- Mutation
- Obesity
- Obesity, Morbid
- Polymerase Chain Reaction