Article
Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat.
Biochemical and biophysical research communications - 6 May 1996
Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K
Abstract excerpt
The mouse obese (ob) gene product (leptin), expressed specifically in adipose cells, regulates energy balance in mice. Both mouse diabetes (db) and rat fatty (fa) gene products are thought to play major roles in leptin signaling pathways in the hypothalamic area. Mutations of these genes in murin...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Gene Expression
- Genes
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Obesity
- Point Mutation
- Polymorphism, Restriction Fragment Length
- RNA, Messenger
- Rats