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Article

Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation.

Diabetes - 1 Jun 2002

Lahlou Najiba, Issad Tarik, Lebouc Yves, Carel Jean-Claude, Camoin Luc, Roger Marc, Girard Jean

Abstract excerpt

A part of serum Ob leptin, an adipocyte-secreted peptide, is bound to a soluble Ob receptor (sObR). Immunoreactive sObR was measured in 125 lean or obese control subjects (group 1), 18 individuals with a mutation in the leptin gene impairing leptin secretion (group 2), and 10 individuals with a mutation in the ObR gene, leading to production of a truncated ObR not anchored to cell membranes (group 3). In group 1,...

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Source

Identifiers

PMID: 12031989
DOI: 10.2337/diabetes.51.6.1980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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