Nitric oxide (NO) disrupts specific DNA binding of the transcription factor c-Myb in vitro.

doi:10.1016/s0014-5793(98)00196-3

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Article

Nitric oxide (NO) disrupts specific DNA binding of the transcription factor c-Myb in vitro.

FEBS letters - 20 Mar 1998

Brendeford E M, Andersson K B, Gabrielsen O S

Abstract excerpt

In an attempt to elucidate signal transduction pathways which may modulate DNA binding of the transcription factor c-Myb, we investigated whether c-Myb could be a target for the signaling molecule nitric oxide (NO) in vitro. NO-generating agents severely inhibited specific DNA binding of the c-My...

Topics

Animals
Avian Myeloblastosis Virus
Chickens
DNA
DNA-Binding Proteins
Dithiothreitol
Glutathione
Mutation
Nitric Oxide
Nitroprusside
Nitroso Compounds
Protein Binding
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-myb
S-Nitrosoglutathione
Trans-Activators

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