Article
Nitric oxide (NO) disrupts specific DNA binding of the transcription factor c-Myb in vitro.
FEBS letters - 20 Mar 1998
Brendeford E M, Andersson K B, Gabrielsen O S
Abstract excerpt
In an attempt to elucidate signal transduction pathways which may modulate DNA binding of the transcription factor c-Myb, we investigated whether c-Myb could be a target for the signaling molecule nitric oxide (NO) in vitro. NO-generating agents severely inhibited specific DNA binding of the c-Myb minimal DNA-binding domain R2R3. This inhibition was readily reversible upon treatment with excess DTT. A...
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