Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nitric oxide-mediated inhibition of Hdm2-p53 binding.

Biochemistry - 19 Nov 2002

Schonhoff Christopher M, Daou Marie-Claire, Jones Stephen N, Schiffer Celia A, Ross Alonzo H

Abstract excerpt

It has become increasingly evident that nitric oxide exerts its effects, in part, by S-nitrosylation of cysteine residues. We tested in vitro whether nitric oxide may indirectly control p53 by S-nitrosylation and inactivation of the p53 negative regulator, Hdm2. Treatment of Hdm2 with a nitric oxide donor inhibits Hdm2-p53 binding, a critical step in Hdm2 regulation of p53. The presence of excess amounts of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Dithiothreitol
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione

Share to Glutathione Transferase

Share to Neoplasm Proteins

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-mdm2

Source

Identifiers

PMID: 12427017
DOI: 10.1021/bi026262q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nitric oxide-mediated inhibition of Hdm2-p53 binding.PMID 12427017Read ↗

Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genomeSemantic proximity Read ↗

Computational Structural Biology of S-nitrosylation of Cancer TargetsSemantic proximity Read ↗

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.Semantic proximity Read ↗

Nitric oxide (NO) disrupts specific DNA binding of the transcription factor c-Myb in vitro.Semantic proximity Read ↗

Nitric oxide destabilizes Pias3 and regulates sumoylation.Semantic proximity Read ↗

Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: Regulation of estrogen-dependent gene transcriptionSemantic proximity Read ↗

Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation.Semantic proximity Read ↗

S-Nitrosylation of the epidermal growth factor receptor: a regulatory mechanism of receptor tyrosine kinase activity.Semantic proximity Read ↗

Disrupted nitric oxide homeostasis impacts fertility through multiple processes including protein quality control.Semantic proximity Read ↗

Nitric oxide dioxygenase: an enzymic function for flavohemoglobin.Semantic proximity Read ↗

Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1.Semantic proximity Read ↗

The Arabidopsis Prohibitin Gene PHB3 Functions in Nitric Oxide-Mediated Responses and in Hydrogen Peroxide-Induced Nitric Oxide Accumulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.