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Article

Probing domain interactions in soluble guanylate cyclase.

Biochemistry - 24 May 2011

Derbyshire Emily R, Winter Michael B, Ibrahim Mohammed, Deng Sarah, Spiro Thomas G, Marletta Michael A

Abstract excerpt

Eukaryotic nitric oxide (NO) signaling involves modulation of cyclic GMP (cGMP) levels through activation of the soluble isoform of guanylate cyclase (sGC). sGC is a heterodimeric hemoprotein that contains a Heme-Nitric oxide and OXygen binding (H-NOX) domain, a Per/ARNT/Sim (PAS) domain, a coiled-coil (CC) domain, and a catalytic domain. To evaluate the role of these domains in regulating the ligand binding...

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Identifiers

PMID: 21491957
DOI: 10.1021/bi200341b
PMCID: PMC3096724

Genes

ARNT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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