Abnormal liver enzyme-mediated metabolism in Parkinson's disease: a second look.

Abstract excerpt

If toxicant exposure contributes to the cause of Parkinson's disease, poor function of detoxifying enzymes could increase vulnerability for Parkinson's disease. Although no hepatic enzyme system has been shown universally to be dysfunctional in Parkinson's disease patients, several have been suggested to be dysfunctional in subgroups, such as those with young age at disease onset. Specific enzymes implicated...

Topics

• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
• Cytochrome P-450 Enzyme System
• Debrisoquin
• Humans
• Liver
• Parkinson Disease
• Phenotype