Article
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha.
Nature - 26 Mar 1998
An W G, Kanekal M, Simon M C, Maltepe E, Blagosklonny M V, Neckers L M
Abstract excerpt
Although hypoxia (lack of oxygen in body tissues) is perhaps the most physiological inducer of the wild-type p53 gene, the mechanism of this induction is unknown. Cells may detect low oxygen levels through a haem-containing sensor protein. The hypoxic state can be mimicked by using cobalt chloride and the iron chelator desferrioxamine: like hypoxia, cobalt chloride and desferrioxamine activate hypoxia-inducible...
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