Article
Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma.
Journal of gastroenterology - 1 Oct 2011
Suzuki Hideto, Murata Kazumoto, Gotoh Takaya, Kusano Masao, Okano Hiroshi, Oyamada Takashi, Yasuda Yoshikazu, Imamura Masatoshi, Kudo Masatoshi, Mizokami Masashi, Sakamoto Atsushi
Abstract excerpt
BACKGROUND: Des-γ-carboxy prothrombin (DCP) is an established tumor marker for hepatocellular carcinoma (HCC), but the precise mechanism of its production remains unknown. We have recently demonstrated that cytoskeletal rearrangement during the phenotypic changes involved in epithelial mesenchymal transition (EMT) plays a crucial role in DCP production through the impairment of vitamin K uptake. However, DCP...
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